A text-book of medical chemistry and toxicology

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Preface To The Fifth Edition

To meet the demands of the increasing number of readers who wish that advances of importance should be embodied, a new edition has been called for. Among the additions mention can be made of "cracked" kerosene, "garage" poisoning, hydrogenated fats, lipins, newer classification of proteins, zymogens, vitamins, fractional analysis of gastric contents, urease method for determining urea, besides numerous revisions of the section dealing with organic and physiologic chemistry.

The opportunity is taken to thank Dr. Melvin O. Saylor, to whom I am indebted for his valuable suggestions.

James W. Holland.

Philadelphia, Pa., August, 191 7.

Preface To The Fourth Edition

Since this book was written there have been many advances in medical chemistry. When deemed worthy of a place in a compendious work they have been incorporated with the text of the successive editions. No pretense of completeness can stand so long as the available space is limited to the dimensions of a handy volume. As in previous editions, so in this, attention is concentrated upon the essentials relating to medicine. Students whose minds may become quickened with desire for wider knowledge will know how to supplement its deficiencies by reference to more detailed treatises. While it has been the aim in this revision to maintain the plan and size that have so far met with favor, some enlargement is necessary to give a more satisfactory presentation of the aid now offered to diagnosis by the chemical laboratory. Extensions have been made to the sections on radium, thorium, uranium, and vanadium; on newer organic compounds of arsenic; the constitution of the carbohydrates and glucosids; the synthetic local anesthetics allied to cocain; the protective enzyms; the hormones, and an entire chapter on the feces. For more exact studies in metabolism and clinical chemistry the following additional tests have been described: SeleivanofPs for levulose, phenolsulphonephthalein for functional activity of the kidneys, Wassermann's for syphilis, Krokiewicz's for bile-pigment, Saloman-Saxl's for cancer, Volhard-Harvey's for chlorids, Folin's for urea, Folin and Macallum's for uric acid, Benedict's for sugar, safranin for sugar, Frommer's for acetone, Hart's for beta-oxybutyric acid, Folin's for ammonia, Tsuchiya's for albumen, Spiegler's for albumen, Meyer's for hemoglobin, Russo's for typhoid fever, Rimini's for formaldehyd, Abderhalden's for pregnancy. A grateful word of acknowledgment is due to Professor Philip B. Hawk and Doctors Melvin A. Saylor and Olaf Bergeim for helpful suggestions in this revision.

James W. Holland.

Philadelphia, Pa.

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