Dental infections, oral and systemic 1923

Front matter

VOLUME II

RESEARCHES ON CLINICAL EXPRESSIONS OF DENTAL INFECTIONS e =e wk ‘= - si »

ty - os

Introduction To Clinical Applications Of New Interpretations

CRAB PERT ITEX<

APPLICATION OF PRECEDING EXPERIMENTAL DATA IN GEINTCAL PRACTICE

CHAPTER LX CIRCULATORY SYSTEM Endocarditis .

Bacteremia .

Raynaud’s Disease Angina Pectoris Heart Block Hemophilia .

Chronic Carditis Myocarditis .

Carditis

Phlebitis

High blood pressure

GAP TER Lx

RESPIRATORY SYSTEM Tuberculosis Dental Infections and Tuberculosis Streptococcal Pneumonia Head Colds .

Asthma

CHAPTER EX PRIMARY AND SECONDARY SEX ORGANS

CHAPTER LXIIT

KIDNEYS AND RELATED EXCRETORY ORGANS Kidney Bladder

SKELETAL AND MUSCULAR SYSTEM Deforming arthritis Osteomyelitis Myositis Cyst and muscle spasm Retained granuloma and rheumatism Osteomyelitis Spinal lesions Osteomalacia

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XII TABLE OF CONTENTS—VOLUME II—CONCLUDED

CHAPTER LXV PAGE ALIMENTARY TRACT AND ASSOCIATED ORGANS Zao Stomach , i AO Gall-bladder ; ; - #252 Gall-stones . ; ; ; FS Intestines. ; ; . . § 258 Stomach ; ; . 259 Intestines. ; ; ~ 3268 Appendix. ; ; ; « 5264 Stomach : 208 Cancer of the stomach . ; A 2Oe CHAPTER LXVI NERVOUS SYSTEM AND SENSE ORGANS. ; Tage Neuritis ; ; . 2h Central nervous system pl S2HO Rheumatic neuritis ; ; 5280 Mental cloud E25 Sleepiness. . ; eos Sleeplessness é ; » + 299 Neuritis let Nervous breakdown ; He) Ve Chorea. «7 abe Nervous exhaustion ; Ole Loss of memory. | Uomo Epidemic lethargic encephalitis ; 2s: Eye a ee Eon Tee Gan ine and retinal hemorrhage ; , . Boo arco : ; ; . S625 Obscure neuralgia , ; ; a ih CHAPTER LXVII SKIN . ISD CHAPTER LXVIII ENDOCRINE SYSTEM ie sy Goiter . é ; S57 Pancreas ; ' ; . “e682 CHAPTER XTX OTHER TISSUES = , ' . . 864 Xerostomia . . 864 Oral herpes . , ; JOR Dental cysts ; OA Apicoectomy Pairste The repair of dentin and cementum. ; Be ets) | CHAPAE Re pox GENERAL DISCUSSION : : ; ; =. W806 CHAPRLE Rie xOcr GENERAL SUMMARY . . 399 CHAPTER LXXII GENERAL CONCLUSIONS . ' . 404

CHARTER [exit RESEARCH INSTITUTES FOR DENTAL DISEASES . . 406

IST OF ILLUSTRATIONS—VOLUME II

262-B. Granuloma-like defensive membrane constructed about the root of an infected tooth, implanted beneath the skin of a rat. Note its high vascularity and intimate contact with the root, which is being absorbed by it. Rats have Spa high defense for streptococcal infections .

262-C. High powers of defensive reactions of the rat. A shows absorption of the cementum by cells with an osteoclastic and defensive function; B, these cells cep aae ue two foramina by chemotaxis .

262-D. High power of one of the (nine a previous ane NGI

263 264 the evidence of a common response to a general force— namely, chemotaxis—by which these cells are attracted to the toxins and the bacteria producing them. They are also able to function as osteoclasts. Each cell is a floating gland carrying antibody and antitoxin to neutralize the antigens and toxins produced by the bacteria. High defense in humans or animals, as demonstrated by this rat, is dependent upon the development and delivery of a large enough quantity of these defensive substances to carry the aggressive warfare to the immediate zone of the streptococcal invader, or as close as is physically possible, the limitation being the physical protection in the mechanical environment which is provided by an infected tooth structure, for the dentin of a single-rooted tooth contains approximately three miles of closed channels suitable for bacterial growth

Roentgenographic appearance of teeth of Case No. 385

Photographic appearance of extracted teeth of Case No. 385. (See Figure 263).

Resistance and susceptibility history chart of Case No. 385. Note nine cases of heart disease in family, with four deaths .

Acute endocarditis in two rabbits from 1 cc. culture from deciduous teeth shown, from child with endocarditis

Fatal endocarditis in a rabbit inoculated with about one-millionth of a gram of organisms from the washings of crushed teeth from a patient with endocarditis. Heart shown in A; the teeth in C and D; B, an aortic arch involvement from another rabbit inoculated from two other teeth from same patient, shown in E and F

Two rabbits with endocarditis from the ava of he apparently normal tooth in the insert. Patient was prostrated by acute endocarditis :

Streptococcal bacteremia: A, a Heoeteriene granuloma of unusually large size, from the second molar shown in B. Bey and G show organisms grown from the blood taken from the median basilic vein on three different occasions. C, organisms in the blood aspirated from the neck; and C, organisms in_a phagocyting leucocyte ,

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Old Patrick. This rabbit lived for twenty-five and one-half months after one inoculation from culture from tooth, Figure 269. He developed first acute rheumatism, then deforming arthritis, had bowed legs, and walked on the sides of his feet

Other views of Old Patrick with his Serie pate Naw withstanding his et deformity, he grew very ces and heavy

Multiple lesions produced in Snyate on a case a recurring streptococcal bacteremia, Case 987 .

Others of the multiple lesions produced by the dene cultures from Case 987 with streptococcal bacteremia

Source of culture for inoculations from Case 987 .

Roentgenographic appearance of teeth, Case 1241 with angina pectoris. Patient apparently improved ;

Effect of implanting a tooth from Case 1241 beneath the ae of arabbit. B, photograph of the encapsulated tooth. C, a photograph of this rabbit’s heart. D, section of the heart muscle showing fatty degeneration. A, a section of the kidney, parenchymatous nephritis

Hemophilia. Case No. 1024. Ronee seats appearance of the teeth. Note the absence of local reaction. Patient nearly dead from spontaneous hemorrhage, chiefly from gums, for three months, and most severe about root-filled teeth. Sée text

Spontaneous hemorrhage in Sai causing death in taenee hours, from culture from tooth, upper right third molar. See Figure 277

Spontaneous hemorrhages in rabbit’ S ane and ene Cans 1024. Many rabbits developed delayed clotting of blood from this culture. Patient greatly improved

Susceptibility history of patient and family. Case No. 1118.

Roentgenographic view of teeth of Case No. 1118 with recurring heart involvement .

Roentgenographic appearance of (earn of patient an myocarditis. Case No. 1346

High angle view of upper right eid areas in Rieu 280. Note difference in periapical appearance .

Section of heart wall of a rabbit which died in ewelee he from spontaneous hemorrhage from tooth culture of Case No. 1346. See also Frontispiece C

Spontaneous hemorrhages in thigh of one rabbit Bt psoas We of another rabbit. Tooth culture from Case No.

Smear from the urine of Cre Ne. 1346, See many pus eae which Tey SPaciaaa after the removal of dental infections

Roentgenographic appearance of fee oF Gx 1335 mith history of severe heart involvement

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Resistance and susceptibility record of family and patient of Case No. 1335. Note five deaths on father’s side

Roentgenographic appearance of teeth of Case 1009, a severely suffering invalid with degenerative arthritis. Note difference in local structural change.

A very severe myocarditis produced in the ern of a fabbit inoculated with culture from Case 1414. A, low power; B, medium power of focalization

High power of severe myocarditis prodteed in the heer aie a rabbit inoculated with culture from Case 1414. Shows extensive necrosis, fibrosis, and vacuolization, which was not yet fatal when chloroformed

Dental conditions of Case No. 1415 with high ee Sige in Figure 294

Dental conditions of Case vo 1414 with jae eee ae in Figure 294

Comparison of bactericidal Sone om two nioods Case 1414, very low; Case 1415, very high. See difference in dental pathology i in Figures 292 and 293 .

Two severe heart lesions produced in rabbits ante with culture from Case No. 1067: A, myocarditis with hypertrophy; B, endocarditis .

Roentgenographic appearance of dental enditions ‘i Cate No. 1057, suffering from severe acidosis, with heart, stomach, and rheumatic involvements

Defensive reaction: A, encapsulated tooth chips; B, organisms in same; C, fibrous encapsulation tissue, very vascular

A severe case of phlebitis, produced in arabbit’s ear by inoculation with a culture from a tooth of a pa who had recently suffered from a severe attack

A dental cyst which produced a high blood pressure reaching above 220, completely relieved by its removal .

Dental infections which produced a condition aerated as pulmonary tuberculosis. After their removal the ee gained fifty-four pounds

Roentgenographic appearance of teeth of es 1153. Note absence of periapical absorption

Roentgenographic appearance of the oneal feean producing a severe neuritis. Case 1120. Second molar has putrescent pulp

Streptococcal pneumonia. Upper view—lungs of rabbit with influenza, not fatal to rabbits. Lower view—lungs of rabbit with influenza plus inoculation with small amount of dental culture, causing death from pneumonia

A pneumonic lung with streptococcal pneumonia from the implanting of an infected tooth beneath the skin, shown also in position in this figure

Roentgenographic appearance of the teeth poate a sensitization reaction as acute recurring colds. Note extensive absorptions of both teeth and bone

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Roentgenographic appearance of teeth, a culture from which produced the ovarian and tubal infections in the next two figures .

Acute ovarian infections produced in rabbits inoculated with cultures from teeth of patients suffering from same

Other ovarian involvements in rabbits from same culture. Case No. 1085

Several ovarian cysts produced from culture from teeth of a patient recently operated for ovarian cyst, shown in B, and cysts on the vas deferens from same culture

A very large ovarian cyst produced in a rabbit from a dental culture

Roentgenographic appearance of teeth of Case 1224, the culture from which produced the ovarian cyst shown in Figure 312. The patient had recently been operated for removal of large ovarian cyst .

The sections of two rabbits showing ovarian cysts produced in from two to four days after inoculation with a culture from the teeth of Case No. 1224

A very purulent uterine and tubal infection produced in a

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Loe rabbit from the dental culture from a patient suffering from - a purulent uterine discharge which entirely disappeared after the removal of her dental infection .

A deep indurated ulcer on the inner surface of the fallopian tube of the rabbit shown in Figure 313

The highly inflamed fallopian tubes, ovaries, and uterus of a rabbit inoculated with a culture from the teeth of a patient with syphilis ;

Acutely inflamed testicles, one from each of three rabbits inoculated from the cultures of. three different teeth of a patient suffering from acute swelling and pain in testicles. He had previously had gonorrheal or syphilitic infection

The teeth from which the cultures were taken producing results shown in Figure 316 ;

A helpless casting of multiple arthritis. She can scarcely move a joint in her body

Roentgenographic appearance of the teeth of the patient, Case No. 1269. This woman is a helpless bedridden cripple and severe sufferer, probably largely brought on by the overload of six pregnancies in seven years together with dental infections

A helpless bedridden arthritic cripple, with bed sores as large as half an orange. Her condition started during pregnancy late in life when she had chronic dental infections

Susceptibility study showing marked susceptibility to kidney involvement, including patient and four members of father’s family. Case No. 692 .

Rabbit reactions to tooth implantations of case in previous figure. A and 1B implanted teeth. C, cast in the rabbit’s urine. D, organisms in the rabbit’s blood. E, casts in the patient’s urine. F and G, nephritic kidney sections .

145 146 147

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LIST OF ILLUSTRATIONS—Continued Tooth from patient with nephritis. See next figure

Tooth of previous figure beneath the skin of a rabbit Deeded a slight local reaction but rabbit developed acute Na as shown in next figure .

Section of nephritic kidney with pus wall

Acute interstitial nephritis produced in a rabbit. A and B, tissue sections showing cellular necrosis and edema. D, both kidneys of injected rabbit, five times normal size. See normal kidney to right, also hypertrophy of adrenals. C, casts fron patient’s urine. Case No. 573

Two of the teeth of previous case Race eine InVOiVvement. Note condensing osteitis, not rarefying .

Susceptibility of previous case, No. 573. Note four cases of death from heart involvement on mother’s side.

Teeth which produced acute and chronic cystitis, which promptly disappeared after their extraction

Paralysis of the bladder with retention, produced in a nit by dental infection. Bladder is twenty times its normal size, as Shown in B. A shows deep ulcer on inner surface of Cistended bladder .

Susceptibility chart of Racca lt Saeirl Petcare Noté Beni cases of death from Bright’s disease on mother’s side. Examination of patient showed same acutely Be ote though unsuspected, at age twenty-eight

Hypertrophied kidney and casts from urine of a rabbit eich developed severe nephritis in sixteen days from the implanted tooth shown, well encapsulated

Casts from urine of a rabbit dying in two days with rdney involvement, from the Ce of an infected tooth beneath the skin

Typical illustration ai eines and aisheowste in et fluids of animals inoculated with a dental culture

Chronic deforming polyarthritis. This woman wasa raon rset cripple, completely helpless for six years. She now walks about her house without even a cane and does beautiful fancywork. Note condensing osteitis, not rarefying, about tooth. Case No. 709.

Some of teeth of previous case of afcenine ie Perce seven years ago

Histological studies of “aac none: A, aneteeeen a trephined cylinder. B, histological section. Note density. C, roentgenographic appearance. Case No. 709

Acute purulent arthritis produced in rabbit from mares oo tooth shown in C of previous figure. Case No. 709

Arthritis of the spine and hips of patient shown in A, and in spines and hips of rabbits inoculated with cultures from his tooth. Case No. 1125

Putrescent unfilled root of cuspid. Tooth Had but slight apical absorption and no fistula

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LIST OF ILLUSTRATIONS— Continued PAGE

341 Shows improvement in the movement of this man’s spine in three months’ time after extraction. A, limit of lateral movement at beginning. B, in three months. C, limitxor forward and backward movement at Lee and D, after three months . 181

342 Susceptibility record of previous case, No. 1125. Noe odcd inheritance; also in columns to right, duration of chief affection was less than that of the dental infection. Spinal disturbance followed an injury plus his focal infection. . ' 182

343 Extreme deforming arthritis produced in a rabbit inoculated with culture from the tooth shown in Figure 340, previous case, No. 1125 i ake#

344 Case of deforming arthritis, pedriden for ie years, progressively getting worse. So greatly relieved by removal of her dental infection and use of a vaccine that she now does her own housework and has for several years. Case No. 896 . 186

345 Roentgenographic appearance of teeth of previous case. This patient had the degenerative type of arthritis, not proliferative. Note difference in alveolar changes. An overgrown segment of mesial root of lower left first molar was uncovered by trephining. The bone ae are shown in the next figure . . WSF

346 B, the overgrown root es to in previous eeu A, section ‘of bone showing original outline of trabeculae. C and D, concentric lamination obliterating a blood vessel . 188 347 Various views of a rabbit paralyzed by an inoculation from dental culture from previous case, No. 896 189

348 Lesions of spine of rabbit shown in Figure 347. A and B, photographs showing diseased vertebrae. C, degenerative necrosis of vertebrae adjoining the spinal cord. D and |e roentgenographic appearance 190

349 Degenerative arthritis of hand of patient, Gas No, 896, aa dislocation due to shortening of flexor and adductor muscles 193

350 Acute deforming arthritis in boy seventeen years of age, bedridden much of the time for four years and crying by the hour with pain. Almost complete absence of alveolar absorption about putrescent teeth. Case No. 381. 194 351 Same boy and some of his handiwork, now greatly improved but deformed for life. Is he happy? ; 1S

302 Rabbit with acute rheumatism, inoculated with a cule non a putrescent lateral shown in B. Note the nearly complete absence of apical absorption . 9G 303 Susceptibility of the preceding case, No. 381. Nee doneenee

of rheumatism on both sides of family , - 198 304 Roentgenographic view showing the free movement of nae

ble which before dental extractions was ankylosed closed . 199 305 Extreme excementosis. Case 311 with carditis. ; > *2Z01 356 Overgrown bicuspid root of Case 311 . 201

357 Osteomyelitis in a rabbit’s hip, produced by the atnye fom the overgrown root tip shown in Figure 356 ; » 202 ial ie

Roentgenographic appearance of a tooth with caries beneath a bridge which two years later produced torticollis on Sa side of neck of Case 455

About two years later, patient again Suffered “ae fortipollis and rheumatism. B shows putrescent lateral incisor apparently producing same; A, the patient’s swollen wrist joints; D and E, rabbits with swollen feet and joints with acute rheumatism, inoculated with culture from putrescent lateral. C shows a lead bar in the tooth socket. Note the psabave appearance of apical area of lateralinB .

Osteomyelitis produced in rabbits from culture ee (een in previous figure: A, normal; B, pathological; C, section normal; D, section ‘pathological

Susceptibility study of Case 1081. Note Fone oi nected susceptibility factors

Roentgenographic appearance i nen of Cae 1081. Nice zone of condensing osteitis surrounding rarefying, particularly of upper right second bicuspid, characteristic of a history of a broken high defense. Patient suffering from acute pain and lameness in right shoulder.

Four views of a rabbit inoculated with culture ae fhe ery, of Case No. 1081. When under anesthesia these neck muscles relaxed. At right, section of the cord and cervical nerves.

Chronic degenerative a of the ie cord of rabbit of previous figure

Three sections of muscle tissue fee ries of ee Bee suffering from torticollis

An acute involvement of the muscles of the uae ae Senco shown in D, related to the cyst shownin Cand B. Operation followed by rapid and marked improvement. A,a ae rabbit inoculated from culture of same

A section from the cyst wall of Cee figure. Bere, osteoclastic activity

A photograph of the contents of ihe me Rane in cae 367. Large crystals are cholesterol .

A small dental cyst before and after eet ot Sete originally a dental granuloma

Roentgenographic appearance of an eoreoeecliig . the eee following an extraction. See Chapter 43, Volume One

Normal articulating surfaces of rabbit’s knee. Note excellent condition of cartilages, capsule, and joint structures .

Pathological articulating surfaces of rabbit’s knee with acute rheumatism. Slightly different plane from previous figure. Note necrosis of posterior cruciate ligament and cartilages

Comparison of normal and arthritic knee joints of rabbits in nearly corresponding planes and different planes from the preceding figures: upper, pathological; lower, normal

Severe spinal lesions produced in rabbits by the injection of cultures from dental infections ; .

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Progressive development of a spinal disease resembling Pott’s from inoculation of a dental culture

Three types of ossification: B, normal; A, profiferative arthritis; C, osteomalacia

Extreme tendency to periodontoclasia ui neon suftetine ain osteomalacia. The systemic background makes this condition easily progressive and, therefore, resistant to treatment.

Two opposite types of reaction in cementum: A, hypocementosis with destruction of cementum in osteomalacia and severe periodontoclasia ; B, hypercementosis with extreme excementosis in patient with broken defense

Susceptibility study showing marked inherited susceptininey from mother’s side for neuritis, nervous breakdown, and stomach trouble. Case No. 965

Roentgenographic appearance of teeth of Case Ne 965 aa stomach and nervous disturbance

Acute stomach ulcer with near perforation, of a Sane inoculated with culture from a tooth of Case No. 965 with stomach involvement

Postings from three a ANS evi btiess ne a Pte: from ihe teeth of a patient suffering from spontaneous hemorrhages. A, shows a complete perforation of a rabbit’s stomach; B, a stomach just eae to Be C, a near perforation ‘of colon :

Digestive tract Ryenene of saint of previous foie A, non-vital molar; B, gall-bladder involvement; C, acute appendicitis; D, an inflammatory TE Eee of the cecum into the colon

Serious dental infections with little tee Sree sen contributed to a very severe cholecystitis. Case No. 445

Roentgenographic appearance of dental infections of a patient suffering from chronic cholecystitis. ey extractions, patient passed fifty-two gall-stones .

pee pale ene related to intestinal stasis and neuritis. Case ©, (52

Susceptibility study of previous case, No. 752, Note five cases of acute stomach involvement on father’s side, with two deaths E

An enormous mandibular cyst with marked displacement of third molar, nearly to neck of eorener process, hee colitis. Case No. 1019 .

Acute appendicitis produced in two ns in succession by planting of same tooth beneath the skin, taken from patient suffering from pain in ees of previous Oe operation ;

Internal and ieee appearances of eee eter appendix of a rabbit with tooth implanted beneath its skin, from Case No. 1346 suffering from a digestive disturbance

Stomach ulcer produced in rabbit by tooth implantation, Case No. 1346 with stomach involvement

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A remarkable instance of inherited susceptibility for stomach involvement. Note six of patient’s immediate relatives suffered from same, with three deaths

A dental infection which produced a tipping of the meee completely relieved by the extraction of the bicuspid. Case Noe L110

Four rabbits were eared with ite ire fon the tooth shown in D, three of which were completely paralyzed from the centers of their spines backward, as shown in A, B, and C. Patient suffered from spasms. Case No. 1001

Paralyzed rabbit, A and B. C, an ulcer on inner surface of its bladder, shown in next figure ;

Site of lesion in spinal nerves in D. E, the paralyzed Meddee twenty times normal size

Photographic appearance of ventral ope a spine, i one destroyed cartilage

Another paralyzed rabbit of this series. A, Leave arora appearance of spine. Note condensing osteitis. B, compression of spinal cord by proliferative osteitis. C, external appearance of rabbit

Lesions in the cortex of the Caan Papi aie develaned acute choreic nervous symptoms, shown in Figure 347

Roentgenographic appearance of the teeth of Case No. 484; patient suffering with rheumatic neuritis and heart, with extreme muscle atrophy

Susceptibility record, Case No. ASA, Note the strongly inherited susceptibility for heart and rheumatism, with four deaths from stroke

Susceptibility record of Case 1178. Note strongly inherited susceptibility for stomach involvement and neuritis .

Roentgenographic appearance of teeth of Case 1178. Note limited periapical absorption about lower first molars. Patient suffered from extreme nervousness

This Rabbit 716 carried or dragged its hind leg from a eters from the tooth shown on opposite page. See next figure

A series of roentgenographic views of progressive development of hip disease in Rabbit 716, shown in ees figure. Culture from tooth in Case 1178

Photographic appearance of heads of femurs on pone; Rabbit 716

Enlarged views of normal Ae Breteea isan a Rabbit 7 16 from Case No. 1178

A smear showing diplococci in pus feat hip ome ‘i Bano a 16 Rabbit 710, which developed paralysis of hind legs from dental culture from Case 1178 . ;

Roentgenographic appearance of econ in the spine a paralyzed rabbit, 710. Case 1178. A, lateral view while living. Note condensing osteitis. D, C, and B, ventral and lateral views. Note condensing osteitis

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LIST OF ILLUSTRATIONS—Continued PAGE 413 Smear from kidney of rabbit with nephritis from dental infection, showing pus cells and streptococci . ; . 294

414 Central nervous system changes in Rabbit 632 with chores nystagmus, torticollis and gyratory movements: A, a focalization in cerebellum of brain; B, pathy degeneration in gray matter of cord 295

415 Lesions in the aortic arch ii Rabbit 429 ; 297 416 Typical degenerative arthritis of joint capsule of Rabbit 624 298 417 Roentgenographic appearance of teeth of Case 1273 with extreme sleepiness ; 300 418 Dental conditions of Case Ne Bons Pate anit spell a insanity coming on as sleeplessness . 300

419 Susceptibility record of Case No. 557, with casa ana marked inherited suscep to nervous breakdown, and mental cloud 302 420 Dental conditions of Case No. 402, ata nervous ‘disturbance

as crying » 304 421 Roentgenographic appearance ae eet) of Cue 1139 ; » OOF 422 Dental condition of Case No. 1082. Mild insanity greatly

improved by removal of dental pathological condition meee 0

423 Susceptibility record of Case 785, with sciatic rheumatism and heart. Note marked hereditary susceptibility, with five deaths from heart involvement on father’s side and one case on mother’s side. . 308 424 Dental conditions of Case No. 1139, sufienine ithe acute neurltis, completely relieved by removal of dental infections . 310

425 Dental condition of Case No. 805, booked for an insane asylum as a bedridden invalid with palsy. Remarkable relief from removal of her dental infections : 310

426 Infected deciduous molars, without once anne evidences of same, which were producing chorea in a child. Case

No. 1402 315 427 Roentgenographic appearance of en of One: es 335, a hysteria and lassitude. See next figure. 316

428 Susceptibility record of Case No. 335. Suffered acute Pes hysteria, heart, and rheumatism. Note ten cases of heart involvement in family. 318

429 Dental condition of Case No. 1365, Bit: mite attacie ws extreme loss of memory. These were occurring with increasing severity and frequency. Very marked relief upon removal of dental infections , 320 430 Dental conditions of Case No. 1317. Patent ahenne fae

lethargic encephalitis . 324 431 Dental conditions of Case No. 904, ath acute inflannee

of the sclera and retina of the right eye. ' 326 432 Dental conditions of Case No. 1087, with complete pindnee

in right eye, left eye one-fifth normal 326

433 Progressive involvement in rabbit’s eye, from edt eeitenes from Case 904 with retinitis. ; . oZe

Of five rabbits inoculated with culture from teeth of Case 904, four developed acute eye involvement. Two shown below have ulcers, and two above acute infection of musculature.

Very extreme excementosis of a molar root, Case No. 1087, with a history of glaucoma resulting in complete blindness of one eye and one-fifth vision in the other. Vision progressively diminishing. Marked Dr ement soHeN ie removal of dental infection

Acute conjunctivitis in rabbit, reser = carer fe infected tooth in D, from Case No. 899 with chronic eye irritation and hip involvement

Extreme eye involvement of Case No. 861. B, C, and D, dental conditions. E and F, progressive stages of acute involvement in rabbit’s eye, inoculated with culture from these teeth

Marked bulging of me eyes, vers No. 1008, as seen in A. Eyes returned to normal in a few weeks’ time, as shown in B

Roentgenographic appearance of teeth of previous case, No.

Very Pred ape desenevations aie Ane oe ait stones a pyorrhetic teeth of previous figure. Case No. 1008

Three rabbits which developed acute exophthalmos following inoculations with dental cultures from preceding case, No. 1008

A ruptured blood vessel in patient Ss eye, ane in i Seah hemorrhage into sclera. B, a hemorrhage into the eyeball of a rabbit from culture of tooth. C, hemorrhage into periosteum and muscles

An acute involvement of both eyes of ren ERE in C. es normal eye of rabbit. B, same eye the day following the inoculation with culture from teeth shown in D. Case No. 987

Dental condition of Case is LL, Sigh Eval Ki ree) complete blindness. No return of attacks at last report, two years after removal of dental infections

Dental condition of patient with acute pain in both ears, chiefly left. Relieved by removal of dental infections .

Obscure neuralgia of dental origin: E, crowned vital ee D, without crown; A, degenerating pulp with calcifications: B, cross section of degenerating pulp with calcifications; C, high power showing hyperemia and dilation of vessels with calcification

Radiographic appearance of eae eeane Seren to an acute herpes zoster, which promptly puss after their removal. Case No. 841

Upper lateral which, when ee ee relieved a distressing itching of the skin. Case No. 1114

Dental condition related to a case of hyperthyroidism in a young woman, aged twenty. Conditions returned rapidly to normal following their removal. Case 628

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450 Roentgenographic appearance of dental conditions of very severe case of exophthalmic goiter with heart involvement. Patient very fan recovered after removal of the dental infections. Case 471. May) 451 Susceptibility record of Case No. 471, ih eae) it! goiter involvement and nervous breakdown. Note marked hereditary susceptibility for nervous system and heart, with six deaths from the latter. 360 452 An enormously hypertrophied ee sh develoned ina rabbit inoculated with a dental culture. ; 362

453 Upper, normal sublingual gland showing lobe and ae a numerous normally functioning lobules or acini; lower, pathological sublingual gland of Case No. 955, showing degenerated lobe. The lobules, or acini, are nearly all destroyed, a few intact but breaking down , 366 455 Typical degenerative necrosis of sublingual Bane of different cases of xerostomia . ; ; abo

456 Xerostomia. Case No. 955. A, rociteeonrnnta appearance of left mandibular second molar; B, photographic appearance of bifurcated mesial root; e, hypertrophied lobules of patient’s sublingual gland ; 370

457 Sublingual, submaxillary, and rd Libres To A, ‘one a normal rabbit; in B, from a rabbit inoculated with a culture from a tooth shown i in 456 Se

458 B, a pair of greatly hypertrophied Saniteral Benak predue in a rabbit from cultures from Case No. 955 with xerostomia and rheumatism. A, an acute suppurative arthritis in same rabbit : Sie