MIT OpenCourseWare

Browse materialsMIT 8.591J · Fall 2004

Systems Biology

Subjects: Biology · Physics

Art: Reinier Vinkeles / Pieter Pietersz Barbiers II, De zaal der physica van Felix Meritis, 1794 · Public domain

Instructor: Prof. Alexander van Oudenaarden
Term: Fall 2004
Level: Graduate
What's inside: 1 lecture note · 1 reading · 45 other files · 4 web pages
Materials open: MIT OCW

Other versions of this course

8.591J · Fall 2014 · Study here
8.591J · Fall 2004 · Study here (this version)

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About this course

Source: MIT OpenCourseWare 8.591J Systems Biology, Fall 2004, Prof. Alexander van Oudenaarden — original course page on ocw.mit.edu ↗. License: CC BY-NC-SA 4.0. Study order: MIT's own listing order, section by section. Taken from MIT's published course files, downloaded from ocw.mit.edu on September 23, 2026. How RedLectern is built.

Materials are grouped the way MIT organized them. A verified, course-wide order has not been established here.

Before you start

Prerequisites are not listed here. Check MIT's own syllabus for this course.

This course’s cited books, in our reading lists: Molecular Biology of the Cell · Molecular Cell Biology

How this course was organized

What's here, and what isn't

A lecture sequence of 25 items is confirmed. Assignment and exam materials exist too, but MIT's own order for them could not be verified, so they're shown as materials below rather than a sequence.

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MIT's page format for this item wasn't recognized clearly enough to place it safely. (2 items)
Referenced in a table, but without MIT's own verified order, so it isn't used to claim a sequence.

Materials by section

Grouped by section, as MIT organized them. Not sequenced or ordered.

Lecture Notes

16 files

Assignments

9 files

Readings

17 files

Other materials from this course

MIT OpenCourseWare, Prof. Alexander van Oudenaarden, 8.591J Systems Biology, Fall 2004.

License: CC BY-NC-SA 4.0 · Edition: Fall 2004 · Open the original course on OCW ↗

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Systems Biology

Before you start

What's here, and what isn't

Not included here

Materials by section

Lecture Notes

Assignments

Readings

Other materials from this course

Lecture 1: Introduction Michaelis-Menten Kinetics

Lecture 2: Equilibrium Binding Cooperativity

Lecture 3: Lambda Phage Multistability

Lecture 4: Multistability (cont.)

Lecture 5: Synthetic Genetic Switches

Lecture 6: Stability Analysis

Lecture 7: Introduction E. coli Chemotaxis

Lecture 8: Fine-tuned versus Robust Chemotaxis Models

Lecture 9: Wrapping up Chemotaxis

Lecture 10: Genetic Oscillators

Lecture 11: Genetic Oscillators (cont.)

Lecture 12: Stochastic Chemical Kinetics

Lecture 13: Stochastic Chemical Kinetics (cont.)

Lecture 14: Introduction Cell Systems Biology Fick’s Laws

Lecture 15: Local Excitation Global Inhibition Theory

Lecture 16: Local Excitation (cont.) Global Inhibition Theory (cont.)

Lecture 17: Rapid Pole-to-pole Oscillations in E. coli

Lecture 18: Rapid Pole-to-pole Oscillations in E. coli (cont.)

Lecture 19: Models for Eukaryotic Gradient Sensing

Lecture 20: Models for Eukaryotic Gradient Sensing (cont.)

Lecture 21: Modeling Cytoskeleton Dynamics

Lecture 22: Modeling Cytoskeleton Dynamics (cont.)

Lecture 23: Quorum Sensing

Lecture 24: Final Problem Set Question Hour

Lecture 25: Drosophila Development