MIT OpenCourseWare

Browse materialsMIT 5.08J · Spring 2016

Biological Chemistry II

Subjects: Biochemistry · Biology · Chemistry

Art: Lascelles, Henry; Paas, John, 1790-1832, Plate II: The Modern Chemical Apparatus. No.2, 1800 · Public domain

Instructors: Prof. Joanne Stubbe, Prof. Elizabeth Nolan
Term: Spring 2016
Level: Undergraduate
What's inside: 67 videos · 9 problem sets · 4 exams · 13 solutions · 1 reading · 49 other files · 4 web pages
Materials open: Videos here · files on MIT OCW

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About this course

Source: MIT OpenCourseWare 5.08J Biological Chemistry II, Spring 2016, Prof. Joanne Stubbe, Prof. Elizabeth Nolan — original course page on ocw.mit.edu ↗. License: CC BY-NC-SA 4.0. Study order: MIT's own listing order, section by section. Taken from MIT's published course files, downloaded from ocw.mit.edu on September 23, 2026. How RedLectern is built.

Materials are grouped the way MIT organized them. A verified, course-wide order has not been established here.

Has MIT solutions 13 files in this course are named by MIT as solutions.

Before you start

Prerequisites are not listed here. Check MIT's own syllabus for this course.

How this course was organized

What's here, and what isn't

This course has 49 videos, each embedded on its own MIT page, across 1 section. They're shown in MIT's listing order within each section. A verified course-wide order is not claimed for this course.

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Materials by section

Grouped by section, as MIT organized them. Not sequenced or ordered.

Lecture & Recitation Videos

18 videos

Assignments

18 problem sets

Exams

8 files

Other materials from this course

48 video transcripts

MIT OpenCourseWare, Prof. Joanne Stubbe, Prof. Elizabeth Nolan, 5.08J Biological Chemistry II, Spring 2016.

License: CC BY-NC-SA 4.0 · Edition: Spring 2016 · Open the original course on OCW ↗

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Biological Chemistry II

Before you start

What's here, and what isn't

Not included here

Materials by section

Lecture & Recitation Videos

Assignments

Exams

Other materials from this course

Lecture 1: Introduction

Lecture 2: Protein Synthesis 1

Recitation 1: Determining, Analyzing, and Understanding Protein Structures

Lecture 3: Protein Synthesis 2

Lecture 4: Protein Synthesis 3

Lecture 5: Protein Synthesis 4

Recitation 2: Pre-Steady State and Steady-State Kinetic Methods Applied to Translation

Lecture 6: Protein Synthesis 5

Lecture 7: Protein Synthesis 6

Lecture 8: Protein Folding 1

Recitation 3: Pre-Steady State and Steady-State Kinetic Methods Applied to Translation

Lecture 9: Protein Folding 2

Lecture 10: Protein Folding 3

Lecture 11: Protein Folding 4

Recitation 4: Purification of Native and Mutant Ribosomes, Protein Purification

Lecture 12: Protein Degradation 1

Lecture 13: Protein Degradation 2

Lecture 14: Protein Degradation 3

Recitation 5: Overview of Cross-Linking, Including Photo-Reactive Cross-Linking Methods

Lecture 15: PK and NRP Synthases 1

Lecture 16: PK and NRP Synthases 2

Recitation 6: Macromolecular Electron Microscopy Applied to Fatty Acid Synthase

Lecture 17: PK and NRP Synthases 3

Lecture 18: PK and NRP Synthases 4

Recitation 7: Application of Single Molecule Methods to Understand Macromolecular Machines And Protein Degradation

19. Cholesterol Biosynthesis 1

Lecture 20: Cholesterol Biosynthesis 2

Lecture 21: Cholesterol Biosynthesis 3 & Cholesterol Homeostasis 1

Recitation 8: Application of CRISPR to Study Cholesterol Regulation

Lecture 22: Cholesterol Homeostasis 2

Lecture 23: Cholesterol Homeostasis 3

Lecture 24: Cholesterol Homeostasis 4

Recitation 9: Cholesterol Homeostasis and Sensing

Lecture 25: Cholesterol Homeostasis 5 & Metal Ion Homeostasis 1

Lecture 26: Metal Ion Homeostasis 2

Lecture 27: Metal Ion Homeostasis 3

Recitation 10: Metal-Binding Studies and Dissociation Constant Determination

Lecture 28: Metal Ion Homeostasis 4

Lecture 29: Metal Ion Homeostasis 5

Recitation 11: Mass Spectrometry

Lecture 30: Metal Ion Homeostasis 6

Lecture 31: Metal Ion Homeostasis 7 & Reactive Oxygen Species 1

Recitation 12: Mass Spectrometry of the Cysteine Proteome

Lecture 32: Reactive Oxygen Species 2

Lecture 33: Reactive Oxygen Species 3

Lecture 34: Reactive Oxygen Species 4 & Nucleotide Metabolism 1

Recitation 13: Fluorescence Methods