Manifesto of plain facts

Front matter

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IUUMIWJIJM

Preface

IN INTRODUCING this Edition to the reader it would be only just and right to give an explanation as to how and w T hy I came to do so. Permit me to say, after I have had a number of years' practical experience in the manufacturing of preparations from animal product for the treatment of indigestion and dyspeptic symptoms, my attention was called to the medicinal properties of pepsin, its source and supply. I handled from 2,000 to 12,000 stomachs daily for four years. I received them in all stages, ranging in condition from the healthiest to the most disordered and inflamed, and I have never found any difference in the amount of pepsin contained therein or in quality, proportional to their weight; the poor animal and the fat being equally supplied, also the pancreas, though thinner and lighter in poor animals than in a fleshier and seemingly healthier one, always contained apparently an equal amount of the pancreatic juice and, having the same properties, being capable of converting equal weight of starch into sugar and emulsifying equal weight of fats. The

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animals, as a rule, were fed and housed alike, still there was a marked difference in their outward appearance and weight, and a greater difference in the composition of their blood and flesh. I found that the poor animal of same age as the sleek and fat one had nearly twice the amount of fluid blood, but of much lighter color, and only about one-half the amount'of fibrin, the red blood corpuscles being much smaller, with very little difference in number.

The blood acid* I found in the lung cells of the poor animal flocks of coagulated blood from hameglobin, the lungs acting as a strainer and retaining all solid substance, upon microscopic examination of the flocks of coagulated hameglobin together with a careful chemical test, the flocks showed marked traces of carbonic acid gas, while the lungs were very much flattened and not of healthy color.

Following up this important discovery I concluded to make a special study of the disordered condition on general principals, selecting for my subject the sheep, and arrangements were made with the butchers to notify me when the government inspectors condemned cattle or sheep, which they did on a number of occasions, and I found a number of condemned animals suffering from the blight of tuberculosis. On microscopic examination I found the stomach in most cases contracted, the muscles and nerves dilated and in some parts

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solidified, while seeming to be almost devoid of plamsa, hence I came to the conclusion that tuberculosis is caused by a disordered condition of the stomach, inducing an abnormal blood supply with an ensuing impoverished nervous system, not containing the elements to produce activity, and that pulmonary tuberculosis is only a secondary trouble, while to successfully remove the bacilli and heal the lungs could only be accomplished by treating ike cause that was producing the trouble. It is a well known fact that the lungs are a bacillicidal, and when properly supplied with motive or muscular power that by the air which they supply sufficient oxygen is taken in the blood to keep the red corpuscles up to highest possible point, and they in turn acting as we might say as the scavengers of the system, by giving up the oxygen, the life-giver, and absorbing in turn the carbonic gas and conveying it again to the lungs for exhalation, the chemical change takes place in the lungs, and carbonic with all obnoxous gasses are exhaled while a fresh supply of oxygen is partaken of, and so continues the work and action of the lungs. Understanding the normal lung function, they may be compared to a mechanical contrivance by way of comparison as a boiler generating steam, of which no use of it can be made until the steam is conveyed through pipes to radiators, where the heat is supplied, or again for motiye power there is steam chest and cylinder; now,

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if for some reason the eccentric should be displaced so the cylinder could take steam from but one end, the force of power would be lost, and the machine would not move; now, in this case, with the engine at fault, if the engineer would say, " I must repair the boiler and raise more steam," what would you think of such a mechanic?

With the mechanism properly adjusted the machine will supply the required force and power; so it is with man, if the nervous system is supplied with the lacking elements they at once supply the muscles of the body with energy, and the muscles are then enabled to perform their respective functions, the lungs are compelled to respond to muscular contraction and the required amount of oxygen is supplied in the blood while obnoxious gasses are expelled, then the blood becomes healthy, as we know the blood is flesh — flesh is blood — and when the blood is healthy the tissues are also; nor if from any cause there is a breaking down or suppuration of tissue, the corpuscles will absorb the same as noxious gas, and convey it to the lung where it is expelled by the chemical action of the lung, and thus by combustion, in due time, the noxious poison is removed while healthy blood prevents its propagation by neutralization and the involved parts are healed.

We all recall the usual questions of many noted physicians to persons affected with pulmonary

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tuberculosis; the first question being, " How long have you been ailing?" " Have you reduced in flesh?" u Have you night-sweats?" " How is your appetite?" After examining the chest if in its incipiency, the physician will advise a bottle of " soand-so" emulsion, take this and that, weigh yourself once each week, etc., etc., most invariably the patient will say: "Doctor, I am so nervous and irritable I can't sleep; can't you give me something? I believe if my stomach did not trouble me I would be all right." The cough at that time being only light, later on the cough becomes more aggravating and the stomach and nerves more upset, then the patient will call again and the physician will say to the patient: "When did you weigh last?" being told, " Have you gained any in weight?" " No, I have lost about three pounds each week notwithstanding that the most nutritious food has been partaken of." After examination the patient will ask the physician; "Well, doctor, what do you think of my case?" After a few moment's hesitancy the reply is: " I do not see much change in your lungs, and I am somewhat disappointed to learn that you have been losing in flesh and strength; now, let me see; how are you fixed financially? If it would be so that you could stand the expense I would advise you to go South," or West, as the case might be, " and take my medicine and rough it; you will be much improved." What are

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the results? about one chance in a hundred to regain his health, and twenty-five chances in one hundred to prolong his suffering for a few years at the most, and in no case have I ever seen where tubercular pulmonalis was cured by climatic treatment so the patients could return to their respective homes and enjoy their cure.

The physicians' trouble and failure in producing a cure in tubercular pulmonalis had for all time been the same; they have been treating the lungs some by inhilation, others by astringents drugs, such as creasote and oil of cloves, and have destroyed the action of the stomach, they have completely ignored the seat of the trouble, and treated the lungs, when, in fact, the lung symptoms are secondary.

The trouble with other so-called " Consumption Cures' has been the same in all cases; their originators started out with a false diagnosis, and were consequently led into errors in the treatment of the disease; upon the other hand, the success of my treatment of the disease is easily attributed to the fact that I have properly diagnosed the real cause of the disease, and went to work systematically upon these lines, and brought forth a specific which contains the missing elements of the nervous system. In other words: I found out what had to be cured, and studied out that cure.

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This I was enabled to do on account of my wide experience in pharmaceutical chemistry and extensive knowledge of the pathological effects of the medicinal products in the manufacturing of which I was for years engaged. Having discovered a positive cure for consumption and kindred diseases, I concluded that a specific that would remove the cause and restore vitality would certainly not be injurious to be partaken of by persons in good health, I then decided to look for that patient, and finally I concluded that I myself would fill the bill. I immediately began to take the remedy, and continued to do so for three months, and I must say I experienced no bad results from its use- At; that time I was 30 years of age, and never knew what it was to be sick. It is now eight years since, and my health is exceptionally good. Having satisfied myself that the medicine was not injurious to the system I then sought for persons who were afflicted with tuberculosis, and I found it to be a very difficult task to induce them to try the remedies while their attending physician held out any encouragement. Then, as a last resort, I concluded to try the remedies on a few cases that were far advanced — and, in fact, had given up all hopes — their physicians informed them or their friends that it was not necessary for the physician to call further, as all that could be done was accomplished, and to be kind and attentive to them as they would not

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live more than a week, or a month at the most. So I selected a number of such patients and treated them, and the results were so favorable that I cured fifty per cent, of those cases. Some of those are to-day well and following their usual occupations. My theory of tuberculosis is a constitutional weakness and that if a cure is to be accomplished that it must be produced only by the increased vitality; hence, it was not proper for me to expect to. cure a patient when their vitality was exhausted, as it is my firm conviction that medicine is only an assistant to nature to throw off the disease, and that no medicine cures of itself, but if properly and judiciously administered will assist nature and vitality to throw off the disease; hence the necessity of having a patient with a fair amount of vitality. A man's vitality can be compared to two horses heavily laden on a rough road that become exhausted and can't draw the load; man coming along with one horse says it represents medicine, and he will say: " Takeoff your horses and replace them with mine, medicine" do you believe that one will accomplish what two failed to? No, but if he places his horse's strength in connection with the other two the three will move along smoothly.

Through the kindness of a noted physician, who allowed me to test the medicine on two of his patients who were afflicted with tuberculosis of the lungs, and in second stage. After a few months'

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treatment they were pronounced cured and physically strong, and returned to their former occupations. During the treatment the attending physician noted their symptoms from day to day, also a number of physicians.

Shortly after, this physician said to me: " Clancy, what do you intend doing with the remedies?" My answer was, I would like to give the cure to the profession but that I was not financially able to, and, another reason, that it would require time to prove the effectiveness of the cure, and that I wished to personally superintend its administration, as a cure was at one time anticipated, when Dr. Koch said his cure was perfect, but when his so-called cured patients returned to work, they were without exception stricken down and died within the year, and I did not want to make an assertion unless I could substantiate the statement with positive cures — who had been cured for at least one year, and who were able to follow their usual occupation, also to live in any climate they chose.

This noted physician informed me that it w^ould be necessary that I have a stock company incorporated under our State laws to administer the remedies only upon the prescription of duly qualified physicians, who should diagnose the patients' disease and prescribe it in proper cases.

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I sought the advise of an attorney who was familiar with corporations law, also the ethics of medical profession. After selecting my associates, men of note, the application was presented to the department of State, State of Illinois. On the ist day of July, 1896, a charter was granted for the organization of the St. Phillip's Special Remedies Company. The remedies are since July 9, 1896, administered by the St. Phillip's Special Remedies Co. The Company is incorporated for ninety-nine years, and have the sole use of the remedies while the Company is in existence. The medicine is only given upon the prescription of qualified physicians, and in no case can the medicine be purchased outside the Company's laboratory, and in no case can it be purchased unless prescribed for. The medicine is not for sale in drug stores nor department stores.

Any physician can forward diagnosis blank giving symptoms and condition, and it in first or second stages would immediately fill the order. But if the patient is in the last stage, would not want to treat such patients, as we could not possibly hope for a cure.

The St. Phillip's Special Remedies Co. have in their Chicago office five regular physicians who make examinations and prescribe the treatment and administer to any and all complications that may arise.

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I will now endeavor to call your attention to the physiological and chemical composition of the body, and if you carefully pursue it you will readily see that chemistry is the main factor, and if judiciously mastered will give the necessary light, so the cause can be located, also by close adherence to the grand and simple leading truths of chemistry, the lesser truths or principals, and nearly all the interesting relationships of elements and compounds. In a word, the science ot chemistry must be dependent to bring out the specific to cure all ailments of man.

Read the book through carefully and note each testimonial, and I believe you will bear me out, and that we are the only Company, or body of men, that can produce a positive cure of that dread disease, viz: Consumption, and Bright's Disease.

We are desirous of having physicians interview us or our cured patients, or those under treatment. Also would be willing to supply the medicine to the profession in different localities, to be given gratuitiously, as on trial cases, providing a diagnosis is forwarded to our office, and the patient is not further advanced than second stage.

We maintain, we can positively cure ninetyeight per cent, of tuberculosis patients by the use

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of our remedies when in first stage, and at least seventy-five per cent, when in second; in third and last stage cannot cure them, but can relieve them and render the tubercular bacilli innocuous, so it cannot be propagated.

Bright's Disease can be cured in all of its stages. When uraemia is very marked, cannot cure them, but at any time before the blood is poisoned with urea can cure the disease; it makes no difference how much oedema is present.

Chapter I

The word Physiology may be used either in a general or in a more restricted sense. In its more general meaning it was used largely of old, and is still occasionally used in popular writing, to denote all inquiry into the nature of living beings. A very slight acquaintance, however, with the phenomena of living beings shows that these can be studied from two apparently very different points of view.

The most obvious and striking character of a living being is that it appears to be an agent, performing actions and producing effects on the world outside itself. Accordingly the first efforts of inquirers were directed towards explaining how these actions are carried on, how the effects of a living being upon its surrounding are brought about. And the dissection or pulling to pieces of the material body of a living being was, under the name of Anatomy {g. v.) regarded as simply an analysis preparatory and necessary to the understanding of vital actions. But it soon became obvious that this anatomical analysis gave rise of itself to problems independent of, or having only distant relations to, the problems which had to do with the actions of living beings. Hence, in course of time a distinct science has grown up which deals exclusively with the laws regulating the form, external and internal, of living beings, a science which does not seek to explain the actions of living beings, and takes note of these actions only when they promise to throw light on the occurence of this or that structural feature. Such a science which is now known under the name of Morphology (q. v.) might be carried on in a world in which all living things had, in the ordinary meaning of the word, become dead. Were the whole world suddenly petrified or were a spell to come over it like that imagined by Tennyson in his Day Dream, but more intense, so that not only the gross visible movements but the inner invisible movements which are at the bottom of growth were all stayed, the morphologisfc would still find ample exercise for his mind in investigating the form and structure of the things which had been alive and which still differed from other things in their outward lineaments and internal build.

In its older sense physiology embraced these morphological problems and so corresponded to what is now called Biology (q. v.); in its more modern sense physiology leaves these matters on one side and deals only with the actions of living beings on their surrounding (the study of these necessarily involving the correlative study of the effect of the surrounding on the living being) and appeals to matters of form and structure only so far as they throw light on problems of actions. Looking forward into the far future we may perhaps dimly discern the day when morphology and physiology will again join hands, and all the phenomena of living beings both those which relate to form and those which relate to action will be seen to be the common outcome of the same molecular process. But that day is as yet most distant, and though occasionally even now the two sciences cross each other's path; action explaining form, and form in turn explaining action, the dominant ideas of the two are so distinct, the one from the other, that each must for a long time yet be developed along its own line. It is proposed to treat in the following pages of physiology in this narrower, more restricted sense.

If any one at the present day making use of the knowledge so far gathered in were to attempt a rough preliminary analysis of the phenomena of action of a living being, for instance, of one of the more complex so-called higher animals — such as man — he might proceed in some such way as the following:

One of the first, perhaps the first and most striking fact about man, is that he moves; his body moves of itself from place to place, and one part of the body moves on another. If we examine any one of these movements, such as the bending of the forearm on the arm, we find that it is brought about by certain masses of flesh called muscles, which from time to time contract — that is, shorten; and these muscles are so disposed that when they shorten and so bring their ends nearer together, certain bones are pulled upon and the arm is bent. Upon further examination it will be found that all the gross movements of the body, both the locomotion of the whole body and the movements of parts upon parts are carried out by the contraction or shortening of muscles. The muscles together with bones, tendons, and other structures, are arranged in various mechanical contrivances, many of them singularly complex; hence the great diversity of movements of which an animal or man is capable; but in all cases the central fact, that which supplies the motive power, is the contraction of a muscle, a shortening of its constituent fibres, whereby its two ends are brought for a while nearer together

When pursuing the analysis farther we attempt to solve the question: Why do muscles contract? We find that the muscles of the body are connected with what is called the central nervous system by certain strands of living matter called nerves; and we further find that, with some few exceptions which need not concern us now, the contractions of muscles are brought about by certain occult invisible changes called nervous impulses which travel along these nerves from the central nervous system to the muscles. Hence, when a nerve is severed the muscles to which the nerve belonged, thus cut adrift from the central nervous system, no longer stirred by impulses reaching it from thence, ceases to contract and remain motionless and, as it were, helpless. Pushing the problem still farther home, and asking how these impulses originate in the central nervous system, we find that this central nervous mass is connected, not only with the muscles by means of nerves which, carrying impulses outward from itself to the muscles, and so serving as instruments of movement, are called motor, or efferent nerves, but also with various surfaces and parts of the body by means of other nerves, along which changes or impulses travel inwards to itself in a centripetal fashion. Moreover, the beginnings or peripheral endings of these other nerves appear to be so constituted that various changes in the surrounding of the body, or internal changes in the body itself, give rise to impulses, which, thus originated, travel inwards to the central nervous system; hence, these nerves are spoken of as sensory or afferent. Such sensory impulses reaching the central nervous system may forthwith issue as motor impulses leading to movements; but on many occasions they tarry within the central mass, sweeping backwards and forwards along particular areas of its substance, thus maintaining for a w r hile a state of molecular agitation and leading to movement at some subsequent period only. Moreover, we have reason to think that molecular disturbances may arise within the central nervous system apart from the advent, either past or present, of any impulses along sensory nerves. Lastly, the presence of these molecular agitations in the central nervous system whether the immediate result of some new afferent impulses or the much delayed and complicated outcome of some impulse which arrived long ago, or the product of internal changes apparently independent of all disturbance from without, and so far spontaneous, may be indicated by corresponding phases of what we speak of as consciousness. We are thus led to conceive of the central nervous system as, chiefly at least, the seat of a molecular

turmoil maintained by multitudinous afferent impulses streaming in along the various afferent

nerves, a turmoil which makes itself felt within as changes of consciousness, and produces effects without by movements wrought through motor nerves and muscles. And one large part of physiology has for its task the unraveling of the laws which govern this turmoil, which determine, in relation to the advent of afferent impulses and the occurrence of intrinsic changes, the issue of motor impulses, and thus the character of the resulting movements.

The movement of man or of an animal are not, however, the only salient facts of its existence.

Equally characteristic of him are the facts, (i) that he from time to time eats and must eat in order to live, and (2) that a supply of fresh air containing a certain quantity of oxygen is indispensable to his remaining alive. Viewed from a chemical point of view an animal body whether dead or alive, is a mass of complex unstable chemical substances, combustible in nature, i. e. y capable of being oxydized, and of being reduced by oxydation to simpler, more stable substances, with a setting free of energy. Combustible in the ordinary sense of the word an animal body is not by reason of the large excess of water which enters into its composition; but an animal body thoroughly dried will in the presence of oxygen burn like fuel, and, like fuel, give out energy as heat. The material products of that combustion are fairly simply consisting of water, carbonic acid, some amonia or nitrogen compounds, and a few salts. And these same substances appear also as the products of that slower combustion which we call decay; for whether the body be burnt swiftly in a furnace or rot away slowly in earth, air, or water, the final result is the same, the union of the complex constituent substance with the oxygen furnished from the air and their reduction thereby to the above-named products with a development of heat, which either, as in the first case, is rapid and appreciable, or, as in the second, is so slow and gradual as to be with difficulty recognized. Moreover, during life also the same conversion, the same oxydation, the same reduction of complex substances to simpler matters, the same setting free of energy present in the former, but absent in the latter, may be noted. The animal body dies daily, in the sense that at every moment some part of its substance is suffering decay, is undergoing combustion; at every moment complex substances full of latent energy are by process of oxydation reduced to simpler substances devoid of energy or containing but little.

This breaking down of complex substance, this continued partial decay, is indeed the source of the body's energy; each act of life is the offspring of an act of death. Each strain of muscle, every throb of the heart, all the inner work of that molecular turmoil of the nervous system of which we spoke above, as well as the chemical labor wrought in the many cellular laboratories of glands and membranes, every throw of the vital shuttle, means an escape of energy as some larger compacted molecule splits into smaller, simpler pieces. Within the body the energy thus set free bears many shapes, but it leaves the body in two forms alone, as heat and as the work done by the muscles of the frame. All the inner labor of the body, both that of the chemical gland-cells, of the vibrating nerve-substance, with its accompanying changes of consciousness, and of the beating heart and writhing visceral muscles, is sooner or later by friction, or otherwise, converted into heat; and it is as heat that the energy devolved in this labor leaves the body. Manifold as seems the body's energy it has but one sourse, the decay of living material, i.e., the oxydation of complex substances diversely built up into various living matters, and but two ends — heat and muscular work. The continued setting free of energy which thus marks the living body, entailing as it does the continued breaking up and decay of living substance, constitutes a drain upon the body which must be met by constantly renewed supplies, or otherwise the body would waste aw r ay and its energy flicker out. Hence, the necessity on the one hand for that which we call food, which, however varied, is essentially a mixture of complex combustible energy holding bodies, and, on the other hand, for that other kind of food, which we call breath, and which supplies the oxygen whereby the complex oxydizable substance may be oxydized to simpler matters and their potential energy made to work. Thus food supplies the energy of the body, but in quantity only, hot in quality. The food by itself, the dead food, can exhibit energy as heat only, with intervening phases of chemical action; before its energy can be turned into the peculiar groves of nervous and muscular action it needs to be transmuted into living substance, and in that transmutation there is a preliminary expenditure of part of the food's store of energy.

Here, then, we have a second view of physiological labor. To the conception of the body as an assemblage of molecular thrills — some started by an agent outside the body, by light, heat, sound, touch, or the like; others begun within the body, spontaneously as it were, without external cause; thrills which, traveling to and fro, mingling with and commuting each other, either end in muscular movements or die away within the body. To this conception we must add a chemicalone that of the dead food continually being changed and raised into the living substance, and of the living substance continually breaking down into the waste matters of the body by processes of oxydation, and thus supplying the energy needed both for the unseen molecular thrills and the visible muscular movements.

Hence, the problems of physiology may in a broad sense be spoken of as threefold: (i) On the one hand, we have to search the laws according to which the, complex unstable food is transmuted into the still more complex and still more unstable living flesh, and the laws according to which this living substance breaks down into simple stable waste products, void, or nearly void, of energy. (2) On the other hand, we have to determine the laws according to which the vibrations of the nervous substance originate from extrinsic and intrinsic causes, the laws according to which these vibrations pass to and fro in the body acting and reacting upon each other, and the laws according to which they finally break up and are lost, either in those swings of muscular contraction whereby the movements of the body are affected or in some other way. (3) And, lastly, we have to attack the abstruse problems of how these neural vibrations, often mysteriously attended with changes of consciousness, as well as the less subtle vibrations of the contracting muscles, are wrought out of the explosive chemical decompositions of the nervous and muscular substances, that is, of how the energy of chemical action is transmuted into and serves as the supply of that vital energy which appears as movement, feeling and thought.