Being well-born: an introduction to eugenics

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•FROM-THE-FUND-BEQUEATHED-BY

AN INTRODUCTION TO EUGENICS

Preface

One of the most significant processes at work in society to-day is the awakening of the civilized world to the rights of the child ; and it is coming to be realized that its right of rights is that of being well-born. Any series of publications, therefore, dealing primarily with the problems of child nature may very fittingly be initiated by a discussion of the factor of well-nigh supreme importance in determining this nature, heredity.

No principles have more direct bearing on the welfare of man than those of heredity, and yet on scarcely any subject does as wide-spread ignorance prevail. This is due in part to the complexity of the subject, but more to the fact that in the past no clear-cut methods of attacking the manifold problems involved had been devised. Happily this difficulty has at least in part been overcome.

It is no exaggeration to say that during the last fifteen years we have made more progress in measuring the extent of inheritance and in determining its elemental factors than in all previous time. Instead of dealing wholly now with vague general impressions and speculations, certain definite principles of genetic transmission have been disclosed. And since it is becoming more and more apparent that these hold for man as well as for plants and animals in general, we can no longer ignore the social responsibilities which the new facts thrust upon us.

PREFACE

Since what a child becomes is determined so largely by its inborn capacities it is of the greatest importance that teachers and parents realize something of the nature of such aptitudes before they begin to awaken them. For education consists in large measure in applying the stimuli necessary to set going these potentialities and of affording opportunity for their expression. Of the good propensities, some will require merely the start, others will need to be fostered and coaxed into permanence through the stereotyping effects of proper habits ; of the dangerous or bad, some must be kept dormant by preventing improper stimulation, others repressed by the cultivation of inhibitive tendencies, and yet others smothered or excluded by filling their place with desirable traits before they themselves come into expression.^

We must see clearly, furthermore, that even the best of pedagogy and parental training has obvious limits. Once grasp the truth that a child's fate in life is frequently decided long before birth, and that no amount of food or hospital service or culture or tears will ever wholly make good the deficiencies of bad "blood," or in the language of the biologist, a faulty germ-plasm, and the conviction must surely be borne home to the intelligent members of society that one thing of superlative importance in life is the making of a wise choice of a marriage mate on the one hand, and the prevention of parenthood to the obviously unfit on the other.

In the present volume it is intended to examine into

PREFACE

the natural endowment of the child. And since full comprehension of it requires some understanding of the nature of the physical mechanism by which hereditary traits are handed on from generation to generation, a small amount of space is given to this phase. Then, that the reader may appreciate to their fullest extent the facts gathered concerning man, a review of the more significant principles of genetics as revealed through experiments in breeding plants and animals has been undertaken. The main applications of these principles to man is pointed out in a general discussion of human heredity. Finally, inasmuch as all available data indicate that the fate of our very civilization hangs on the issue, the work concludes with an account of the new science of eugenics which is striving for the betterment of the race by determining and promulgating the laws of human inheritance so that mankind may intelligently go about conserving good and repressing bad human stocks.

In order to eliminate as many errors as possible and to avoid oversights I have submitted various chapters to certain of my colleagues and friends who are authorities in the special field treated therein. While these gentlemen are in no way responsible for the material of any chapter they have added greatly to the value of the whole by their suggestions and comments. Thus I am indebted to Professor Leon J. Cole for reading the entire manuscript; to Professors A. S. Pearse and F. C. Sharp for reading Chapter VII; to Professor C. R. Bardeen for reading special parts;

PREFACE

to Doctor J. S. Evans for reading Chapter VI and part of V; to Doctor W. F. Lorenz, of the Mendota Hospital, for reading Chapter VIII ; to Judge E. Ray Stevens for reading Chapter IX, and to Helen M. Guyer for several readings of the entire manuscript.

Grateful acknowledgment is made to all of these readers, to various publishers and periodicals for the use of certain of the illustrations, to the authors of the numerous books and papers from which much of the material in such a work as this must necessarily be selected, and to my artist, Miss H. J. Wakeman, for her painstaking endeavors to make her work conform to my ideas of what each diagram should showa

M. F. G.

Contents

I Heredity 1

Blood heritage — Kind determined by origin — Ancestry a network — Ancestry in royalty — Offspring derived from one parent only — Dual ancestry an aid in studying heredity — Reversion — Telegony — Prenatal influences apart from heredity— Parent body and germ not identical — A hereditary character defined — Hereditary mingling a mosaic rather than a blend — Determiners of characters, not characters themselves, transmitted — Our knowledge of heredity derived along three lines — The method of experimental breeding — The statistical method — Galton's law of regression — Correlations between parents and offspring — The biometrical method, statistical, not physiological — Mental as well as physical qualities inheritable.

II The Bearers of the Heritage 20

Chapter II

Before we can make any detailed analysis of the inheritance of characters we should have some general idea of the physical structure of animals and particularly some familiarity with the development of an individual from the egg, as well as some knowledge of the nature of the germ-cells.

The Cell the Unit of Structure. — If we examine one of the higher animals, as, for example, the horse, the dog, or man, we find that it is made up of a large number of constituents, such as bones, muscles, nervous elements, blood and other tissues. Each kind of tissue is composed of a number of living units, ordinarily microscopic in size, which are known as cells. A careful examination of various cells reveals that although they may differ greatly in size, shape and minor details, they all alike possess certain well-marked characteristics. Each when reduced to its fundamental form is seen to consist of a small mass of living matter termed protoplasm in which may usually be distinguished two regions — the cell-body or cytoplasm, and the nucleus (Fig. 3, p. 21). Any cell, whether it be of the brain, of the liver, or from any organ of an animal or plant, has this same fundamental structure. In addition, a limiting membrane or wall of some kind is generally present, although it is not a necessary constituent of all cells.

Unicellular Organisms. — While such a structure as a tree or a horse is composed of countless millions

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Importance of Cell-Theory. — This discovery that every living thing is a single cell or an aggregation of cooperating cells and cell-products is one of our most important biological generalizations because it has brought such a wide range of phenomena under a common point of view. In the first place, the structure of both plants and animals is reducible to a common fundamental unit of organization. Moreover, both physiological and pathological phenomena are more readily understood since 'we recognize that the functions of the body in health or disease are in large measure the result of the activities of the individual cells of the functioning part. Then again, the problems of embryological development have become much more sharply defined since it could be shown that the tgg is a single cell and that it is through a series of divisions of this cell and subsequent changes in the new cells thus formed that the new organism is built up. And lastly, the problem of hereditary transmission has been rendered more definite and approachable by the discovery that the male germ is likewise a single cell, that fertilization of the egg is therefore the union of two cells, and that in consequence the mechanism of inheritance must be stowed away somehow in these two cells.

Heredity in Unicellular Forms. — In unicellular animals one can readily see how it is possible for an individual always to give rise to its own kind. One of the simplest of the single-celled animals is the Ameba (Fig. 4, p. 24).

The ameba eats and grows as do other animals. Sooner or later it reaches a size beyond which it can not increase advantageously, yet it is continuously taking in new food material which stimulates it to further growth. Here then is a problem. The ameba solves this difficulty by dividing to form two amebse. Such a division is illustrated in Fig. 4, p. 24. First the nucleus divides, then the cell-body. When the two new ameba? separate completely each renews the occupation of eating and growing. But what has become of the parent? Here, where once existed a large adult ameba are two young amebse. The parent individual as such has disappeared, yet there has been no death, for we have simply two bits of living jelly in place of one. They will in turn repeat the same process, so will their offspring, and thus, barring accident, this growth and reproduction, or overgrowth as we may regard it, may go on forever, as far as we know. Here the problem of heredity, or the resemblance of offspring to parent, is not a very complicated one. The substance of the cell-body and cell-nucleus divides into two similar halves, so that each descendant has the substance of the parent in its own body, only it has but half as much. It differs from the parent, not in quality or kind, but in size.

Reproduction and Heredity in Colonial Protozoa. — There are enormous numbers of these single-celled animals existing in all parts of the world. Some are simple like the ameba, others are very complex in structure. Many, after division, move apart and pur-

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Fig. 4

Six successive stages in the division of Ameba polypodia (after Schulze). The nucleus is seen as a dark spot in the interior.

sue wholly independent courses of existence. On the other hand we find a modification appearing in some which is of the greatest importance. After division instead of moving apart the two cells may remain side by side and divide further to form two more, these in turn may divide and thus the process goes on until there is formed what is known as a colony. Each cell of such a colony resembles the original ancestral cell because each is a part of the actual substance of that cell. As in the ameba, the first two cells are the ancestral cell done up in two separate packets, and thus finally the full quota of cells must be so many separate packets of the same kind of material. Inasmuch as each is but a repetition of its original ancestor, it can, and at times does, produce a colony of the same kind as that ancestor produced.

Conjugation. — At longer or shorter intervals, however, we find that two individuals, on the disruption of the old colony, instead of continuing the routine of establishing new colonies through a series of cell divisions, very radically alter their behavior. They unite and fuse into a single larger individual. This process is called conjugation. We find it occurring even in some species of ameba. The conjugating cells in some colonies are alike in size and appearance, in others different.

Specialization of Sex-Cells. — A beautiful sphereshaped colony known as Volvox is to be found occasionally in roadside pools. Depending on the species of Volvox to which it belongs, the colony may be made up of from a few hundred to several thousand individuals arranged in a single layer about the fluidfilled center of the sphere and bound together by a clear jelly-like inter-cellular substance. Each individual cell also connects with its neighbors by means of thin threads of living matter. One of the largest species is Volvox globator, one edge of which is represented in Fig. 5, p. 27. Mutual pressure of the cells gives them a polygonal shape when viewed from the surface. Each cell, with a few exceptions to be noted immediately, bears two long flagella, whip-like structures which project out into the water. The lashing of these flagella gives the ball a rotary motion and thus it moves about. When the colony has reached its adult condition and is ready to reproduce itself, certain cells without flagella and somewhat larger than the ordinary cells become more rounded in outline and increase considerably in size through the acquisition of food materials. They are then known as egg cells or ova. Each ovum finally enters on a series of cell-divisions forming a mass of smaller and smaller cells which gradually assumes the form of a hollow sphere like the parent colony. The young colonies thus formed drop into the interior of the parent colony to escape later to the outside as independent swimming organisms when the old colony dies and disintegrates. The Fertilized Ovum Termed a Zygote. — After a number of generations of such asexual reproduction, sexual reproduction occurs. The ova arise as usual. Certain members of the colony, on the other hand, go to the other extreme and divide up into bundles of from sixty-four to one hundred twenty-eight minute slender cells, each provided with flagella for locomotion. When mature these small flagellate cells, now known as spermatozoa, escape into the interior of the parent colony and swim about actively. Ultimately each ovum is penetrated by a spermatozoon, the two cells fuse completely and thus form the single fertilized ovum or zygote. The body-cells of the mother colony finally disintegrate. After a period of rest each zygote, through a series of cell-divisions, develops into an adult Volvox. In some species of Volvox a still further advance is seen, in that instead of both kinds of gametes being produced in the same colony, the ova may be produced by one colony and the spermatozoa

Fig. 5

Volvox globator (from Hegner after Oltmanns). Half of a sexually reproducing colony : o, eggs ; s, spermatozoa.

by another. Here, then, we have the foreshadowings of two sexes as separate individuals, a phenomenon of universal occurrence among the highest forms of animal life.

Advancement Seen in the Volvox Colony. — In the Volvox colony there is a distinct advance over the conditions met with in various lower protozoan colonies in that only certain individuals of the colony take part in the process of reproduction and these individuals are of two distinct types ; one is a larger, food-laden cell or egg and the other a small, active, fertilizing cell. The motile forms are produced in much greater numbers than the eggs, plainly because they have to seek the egg and many will doubtless perish before this can be accomplished. This disparity in number is only a means of insuring fertilization of the egg. The remaining cells of the body carry on the ordinary activities of the colony such as locomotion and nutrition and have ceased to take any part in the production of new colonies.

Natural Death Appears With the Establishment of a Body Distinct from, the Germ. — Volvox is an organism of unusual interest because in it we see a prophecy of what is to come. Although still regarded as a colony of single-celled individuals, it represents in reality a transition between the whole group of unicellular animals termed protozoa and the many celled animals characterized by the possession of distinct tissues, known as Metazoa. Moreover, it shows an interesting stage in the establishment of a body or soma distinct from special reproductive cells which have taken on the function of reproducing the colony. In such colonial forms natural death is found appearing for the first time, the reproductive cells alone continuing to perpetuate the species. Then again Volvox represents an important step in the establishment of sex in the animal kingdom for in its sexual reproduction the conjugating cells known as gametes are no longer alike in appearance but have become differentiated into definite ova and spermatozoa.

In Volvox as in the other organisms which we have studied we find that all of the cells including the germ-cells are produced by the repeated division of a parent cell, and consequently each must contain the characteristic living substance of that parent. Many other forms might be cited to illustrate reproduction in single-celled animals, whether free or in colonies, but all such cases would be practically but repetitions or modifications of those we have already examined.

Specialization in Higher Organisms. — If we pass on to the higher animals and plants which are not single cells or colonies of similar cells but organisms made up of many different kinds of cells, we find a pronounced extension of the phenomenon met with in Volvox. Instead of each cell executing independently all of the life relations, certain ones are set apart for the performance of certain functions to the exclusion of other functions which are carried on by other members of the aggregation. Thus the organism as a whole has all the life relations carried on, but, as it were, by specialists.

Sexual Phenomena in Higher Forms. — In the reproduction of multicellular organisms, one sees likewise but a continuation of the phenomena exhibited in Volvox. Ordinarily, each new form is produced by the successive divisions of a single germ-cell which in the vast majority of cases has conjugated with another germ-cell. In the development of the egg, as the divisions proceed, groups of cells become modified for their particular work until the entire organism is completed. During development certain cells are set apart for reproduction of the form just as they were in

Volvox. These two kinds of reproductive cells in multicellular organisms are derived ordinarily from two separate individuals known as male and female, though there are some exceptions. The main difference between these cells which will have to unite to form a single fertile germ-cell, is that they have specialized in different directions ; one is small and active, the other large, food-laden and passive. But with two such germ-cells coming as they do from two individuals, one the male, the other the female, it is obvious that the actual living substance of which each germ is composed will be distinctive of its own parental line and that when the germs unite these distinctive factors commingle, hence the complications of double ancestry arise.

Structure of the Cell. — Before we can understand certain necessary details of the physical mechanism of inheritance we must inquire a little further into the finer structure of the cell and into the nature of cell division. A typical cell, as it would appear after treatment with various stains which bring out the different parts more distinctly, is shown in Fig. 3, p. 21. Typical, not that any particular kind of living cell resembles it very closely in appearance, but because it shows in a diagrammatic way the essential parts of a cell. In the diagram, there are two well-marked regions ; a central nucleus and a peripheral cell-body or cytoplasm. Other structures are pictured but only a few of them need command our attention at present. At one side of the nucleus one observes a small flot or granule surrounded by a denser area of cytoplasm. This body is called the centrosome. The nucleus in this instance is bounded by a well-marked nuclear membrane and within it are several substances. What appear to be threads of a faintly staining material, the linin, traverse it in every direction and form an apparent network. The parts on which we wish particularly to rivet our attention are the densely stained substances scattered along or embedded in the strands of this network in irregular granules and patches. This substance is called chromatin. It takes its name from the fact that it shows great affinity for certain stains and becomes intensely colored by them. This deeply colored portion of the cell, the chromatin, is by most biologists regarded as of great importance from the standpoint of heredity. One or more larger masses of chromatin or chromatinlike material, known as chromatin nucleoli, are often present, and not infrequently a small spheroidal body, differing in its staining reactions from the chromatinnucleolus and sometimes called the true nucleolus, exists.

Cell-Division. — In the simplest type of cell-division the nucleus first constricts in the middle, and finally the two halves separate. This separation is followed by a similar constriction and final division of the entire cell-body, which results in the production of two new cells. This form of cell-division is known as simple or direct division. Such a simple division, while found in higher animals, is less frequent and apparently much less significant than another type of division which involves profound changes and rearrangements of the nuclear contents. The latter is termed mitotic or indirect cell-division. Fig. 6, p. 33, illustrates some of the stages which are passed through in indirect cell-division. The centrosome which lies passively at the side of the nucleus in the typical cell (Fig. 6a, p. 33) awakens to activity, divides and the two components come to lie at the ends of a fibrous spindle. In the meantime, the interior of the nucleus is undergoing a transformation. The granules and patches of chromatin begin to flow together along the nuclear network and become more and more crowded until they take on the appearance of one or more long deeply-stained threads wound back and forth in a loose skein in the nucleus (Fig. 6b, p. 33). If we examine this thread closely, in some forms it may be seen to consist of a series of deeply-stained chromatin granules packed closely together intermingled with the substance of the original nuclear network.

As the preparations for division go on the coil in the nucleus breaks up into a number of segments which are designated as chromosomes (Fig. 6c, p. 33). The nuclear membrane disappears. The chromosomes and the spindle-fibers ultimately become related in such a way that the chromosomes come to lie at the equator of the spindle as shown in Fig 6d, p. 33. Each chromosome splits lengthwise to form two daughter chromosomes which then diverge to pass to the poles of the spindle (Figs. 6e and /, p. 33). Thus each end of the spindle comes ultimately to be occupied by a set of chromosomes. Moreover each set is a duplicate of the other, because the substance of any individual chromosome in one group has its counterpart in the other. In fact this whole complicated system of indirect division h

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Fig. 6

Diagram showing representative stages in mitotic or indirect cell-division : a, resting cell with reticular nucleus and single centrosome ; b, the two new centrosomes formed by division of the old one are separating and the nucleus is in the spireme stage; c, the nuclear wall has disappeared, the spireme has broken up into six separate chromosomes, and the spindle is forming between the two centrosomes ; d, equatorial plate stage in which the chromosomes occupy the equator of the spindle ; e, f, each chromosome splits lengthwise and the daughter chromosomes thus formed approach their respective poles ; g, reconstruction of the new nuclei and division of the cell body ; h, cell-division completed.

is regarded by most biologists as a mechanism for bringing about the precise halving of the chromosomes.

The chromosomes of each group at the poles finally fuse and two new nuclei, each similar to the original one, are constructed (Figs. 6g and h, p. 33). In the meantime a division of the cell-body is in progress which, when completed, results in the formation of two complete new cells.

As all living matter if given suitable food, can convert it into living matter of its own kind, there is no difficulty in conceiving how the new cell or the chromatin material finally attains to the same bulk that was characteristic of the parent cell. In the case of the chromatin, indeed, it seems that there is at times a precocious doubling of the ordinary amount of material before the actual division occurs.

Chromosomes Constant in Number and Appearance.— With some minor exceptions, to be noted later, which increase rather than detract from the significance of the facts, the chromosomes are always the same in number and appearance in all individuals of a given species of plants or animals. That is, every species has a fixed number which regularly recurs in all of its cell-divisions. Thus the ordinary cells of the rat, when preparing to divide, each display sixteen chromosomes, the frog or the mouse, twenty-four, the lily twenty-four, and the maw-worm of the horse only four. The chromosomes of different kinds of animals or plants may differ very much in appearance. In some they are spherical, in others rod-like, filamentous or perhaps of other forms. In some organisms the chromosomes of the same nucleus may differ from one another in size, shape and proportions, but if such differences appear at one division they appear at others, thus showing that in such cases the differences are constant from one generation to the next.

Significance of the Chromosomes. — The question naturally arises as to what is the significance of the chromosomes. Why is the accurate adjustment which we have noted for their division necessary ? The very existence of an elaborate mechanism so admirably adapted to their precise halving, predisposes one toward the belief that the chromosomes have an important function which necessitates the retention of their individuality and their equal division. Many biologists accept this along with other evidence as indicating that in chromatin we have a substance which is not the same throughout, that different regions of the same chromosome have different physiological values.

When the cell prepares for divisions, the granules, as we have seen, arrange themselves serially into a definite number of strands which we have termed chromosomes. Judging from all available evidence, the granules are self -propagating units; that is, 'they can grow and reproduce themselves. So that what really happens in. mitosis in the splitting of the chromosomes is a precise halving of the series of individual granules of which each chromosome is constituted, or in other words each granule has reproduced itself. Thus each of the two daughter cells presumably gets a sample of every kind of chromosomal particle, hence, the two cells are qualitatively alike. To use a homely illustration we may picture the individual chromosomes to ourselves as so many separate trains of freight cars, each car of which is loaded with different merchandise. Now, if every one of the trains could split along its entire length and the resulting halves each grow into a train similar to the original, so that instead of one there would exist two identical trains, we should have a phenomenon analogous to that of a dividing chromosome.

Cleavage of the Egg. — It is through a series of such divisions as these that the zygote or fertilized egg-cell builds up the tissues and organs of the new organism. The process is technically spoken of as cleavage. Cleavage generally begins very shortly after fertilization. The fertile egg-cell divides into two, the resulting cells divide again and thus the process continues, with an ever-increasing number. of cells.

Chief Processes Operative in Building the Body. — Although of much interest, space will not permit of a discussion in detail of the building up of the special organs and tissues of the body. It must suffice merely to mention the four chief processes which are operative. These are, (1) infoldings and outfoldings of the various cell complexes ; (2) multiplication of the component cells; (3) special changes (histological differentiation) in groups of cells ; and (4) occasionally resorption of certain areas of parts.

The Origin of the New Germ-Cells. — On account of the unusual importance from the standpoint of inheritance, which attaches to the germ-cells, a final word must be said about their origin in the embryo. While the evidence is conflicting in some cases, in others it has been well established that the germ-cells are set apart very early from the cells which are to differentiate into the ordinary body tissues. Fig. 7 A, p. 38, shows a section through the eight-celled stage of Miastor, a fly, in which a single large, primordial germ-cell {p. g. c.) has already been set apart at one end of the developing embryo. The nuclei of the rest of the embryo still lie in a continuous protoplasmic mass which has not yet divided up into separate cells. The densely stained nuclei at the opposite end of the section are the remnants of nurse-cells which originally nourished the egg. Fig. 7B, p. 38, is a longitudinal section through a later stage in the development of Miastor; the primitive germ-cells (oog) are plainly visible. Still other striking examples might be cited. Even in vertebrates the germ-cells may often be detected at a very early period.