MIT OpenCourseWare
Quantitative Genomics
Art: after Jan Kalkar, Vesalius - Opera, 1725. Fig. 597, 1725 · Public domain
- Instructors
- Prof. Isaac Kohane, Prof. Leonid Mirny, Prof. Robert Berwick, Dr. Alvin Kho
- Term
- Fall 2005
- Level
- Graduate
- What's inside
- 1 lecture note · 1 reading · 25 other files · 5 web pages
- Materials open
- MIT OCW
About this course
Source: MIT OpenCourseWare HST.508 Quantitative Genomics, Fall 2005, Prof. Isaac Kohane, Prof. Leonid Mirny, Prof. Robert Berwick, Dr. Alvin Kho — original course page on ocw.mit.edu ↗. License: CC BY-NC-SA 4.0. Study order: none is claimed; materials are grouped by MIT's own sections. Taken from MIT's published course files, downloaded from ocw.mit.edu on September 23, 2026. How RedLectern is built.
Materials are grouped the way MIT organized them. A verified, course-wide order has not been established here.
Has MIT solutions
Before you start
Prerequisites are not listed here. Check MIT's own syllabus for this course.
How this course was organized
What's here, and what isn't
- MIT lists a session calendar for this course, but it could not be verified well enough to build a sequence from it — materials are grouped by section instead.
Not included here
15 items from the source could not be safely included:
- MIT's page format for this item wasn't recognized clearly enough to place it safely. (14 items)
- Referenced in a table, but without MIT's own verified order, so it isn't used to claim a sequence.
Materials by section
Grouped by section, as MIT organized them. Not sequenced or ordered.
Lecture Notes
10 files
- Introduction - Prof. Leonid Mirny Download
- The Basic Forces of Evolution: Mutation, Recombination and Mating, Migration, Neutral Evolution and Drift, Effective Population Size Download
- Selection, Fitness, Probability of Fixation, Coalescent Theory Parameter Estimation Download
- Selection, Fitness, and Diffusion Models Molecular Evolution, Jukes-Cantor Model, Kimura Model Download
- Medical Lecture: Human Variations Genes, Genotypes and Generations - Dr. Marco Ramoni (Courtesy of Dr. Marco Ramoni. Used with permission.) Download
- Overview of Protein Structures, Domain Architecture Sequence-structure Mapping, Protein Folding, Forces and Interactions Download
- Structure-based Substitution Matrices Download
- Gene Regulation and Function, Conservation, Detecting Regulatory Elements Download
- RNA Expression: Clustering and Classification Download
- RNA Expression: Classification, 2-way Clustering, Regulatory Modules Integration of Expression and Proteomic Data Download
Assignments
13 files
- This resource includes special .txt file to support the assignment (F10Blat.txt) Download
- This resource includes special .txt file to support the assignment (F10Human.txt) Download
- This resource includes information on the significant-digit law, and its classical explanations (hill_stat_der_96.pdf) Download
- This resource includes information on natural selection: from the basic dynamical system equation… (hst4.pdf) Download
- Assignment 1 · Solutions (Courtesy of Ken Roach. Used with permission.) Download
- Assignment 2 · Solutions (Courtesy of Ken Roach. Used with permission.) Download
- Assignment 1 Download
- Assignment 2 Download
- Assignment 3 Download
- SerProteases_PS3.pdb [Overlapped structures of serine proteases.] Download
- This resource includes special .txt file to support the assignment 1 (cSNPs.txt) Download
- This resource includes special .m file to support the assignment 1 (parseBLATAlignment.m) Download
- [Human SNP data] SNPData.mat Download
Study Materials
MIT OpenCourseWare, Prof. Isaac Kohane, Prof. Leonid Mirny, Prof. Robert Berwick, Dr. Alvin Kho, HST.508 Quantitative Genomics, Fall 2005.
License: CC BY-NC-SA 4.0 · Edition: Fall 2005 · Open the original course on OCW ↗
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