MIT OpenCourseWare

Browse materialsMIT 20.462J · Spring 2006

Molecular Principles of Biomaterials

Subject: Biology

Art: Robert Hooke, Micrographia Scheme 07, 1665 · Public domain

Instructor: Prof. Darrell Irvine
Term: Spring 2006
Level: Graduate
What's inside: 10 problem sets · 1 lecture note · 1 reading · 58 other files · 4 web pages
Materials open: MIT OCW

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About this course

Source: MIT OpenCourseWare 20.462J Molecular Principles of Biomaterials, Spring 2006, Prof. Darrell Irvine — original course page on ocw.mit.edu ↗. License: CC BY-NC-SA 4.0. Study order: MIT's own listing order, section by section. Taken from MIT's published course files, downloaded from ocw.mit.edu on September 23, 2026. How RedLectern is built.

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Materials by section

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Lecture Notes

45 files

Assignments

10 problem sets

Exams

Other materials from this course

9 files

MIT OpenCourseWare, Prof. Darrell Irvine, 20.462J Molecular Principles of Biomaterials, Spring 2006.

License: CC BY-NC-SA 4.0 · Edition: Spring 2006 · Open the original course on OCW ↗

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Molecular Principles of Biomaterials

Before you start

What's here, and what isn't

Not included here

Materials by section

Lecture Notes

Assignments

Exams

Other materials from this course

Lecture 1: Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials Biodegradable Polymeric Solids Chemistry and Physical Chemistry of Hydrolysis Links between Materials Structure and Hydrolysis Mechanisms

Lecture 2: Biodegradable Polymeric Solids (cont.) Factors Controlling Polymer Degradation Rates Theory of Solid Polymer Erosion Tailoring Degradable Polymer Structure and Composition

Lecture 3: Controlled Release Devices Types of Controlled Release Devices Degradable Materials in Controlled Release Devices Physical Chemistry Principles in Delivering Small Molecules vs. Proteins

Lecture 4: Controlled Release Devices (cont.) Theory of Drug Release in Eroding Systems

Lecture 5: Case Studies in Complex Controlled Release Pulsatile Release from Programmed Eroding Systems Controlled Release Microchips Combining Drug Delivery with Tissue Engineering

Lecture 6: Hydrogels as Biomaterials Hydrogel Structure and Physical Chemistry Methods of Polymerization

Lecture 7: Hydrogels as Biomaterials (cont.) Theory of Hydrogel Swelling Physical Hydrogels Ionic and Hydrogen Bonding in Gels Association of Amphiphilic Block Copolymers

Lecture 8: Hydrogels as Biomaterials (cont.) Polyelectrolyte Hydrogels Coacervates Polyelectrolyte Multi-layers

Lecture 9: Hydrogels as Biomaterials (cont.) Theory of Polyelectrolyte Gel Swelling

Lecture 10: Hydrogels as Biomaterials (cont.) Applications of Hydrogels: Molecular Imprinting Applications of Hydrogels: Glucose-sensitive Drug Delivery Kinetics of Drug Diffusion Through Hydrogels

Lecture 11: Engineering Biological Recognition of Biomaterials Biological Recognition in Vivo Protein-resistant and Cell-resistant Surfaces Engineering Recognition of Biomaterials: Adhesion and Migration

Lecture 12: Engineering Biological Recognition of Biomaterials (cont.) Enzymatic Recognition of Biomaterials Cytokine Signaling from Biomaterials

Lecture 13: Engineering Biological Recognition of Biomaterials (cont.) Mimicking Cell-cell Contacts with Surfaces

Lecture 14: Bioceramics and Biocomposites Introduction to Biological Approaches to Biomineralization Interfacial Biomineralization

Lecture 15: Bioceramics and Biocomposites (cont.) Biological Control of Mineralization within Vesicles Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches

Lecture 16: Bioceramics and Biocomposites (cont.) Theory of Controlled Nucleation Bone Structure and Bone Biomimesis Biocomposites in Device Applications and Drug Delivery

Lecture 17: Molecular Devices Molecular Switches via Proteins and ‘Smart’ Polymers Temperature, pH, and Light-sensitive Switches Molecular Motors Kinesin-based Molecular Shuttles ATP Synthase-based Nano-rotors

Lecture 18: Nanoparticle and Microparticle Biomolecule Drug Carriers Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles Delivery of Drugs to Tissues via Systemic Circulation Materials for Anti-Cancer Drug Delivery

Lecture 19: Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.) Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues ‘Stealth’ Particles Theory of Protein-resistant Particles Experimental Function of Long-circulating Carriers and PEGylated Compounds

Lecture 20: Basic Biology of Vaccination and Viral Infections Rudiments of Adaptive Immunity: The Basis of Vaccination Viral Infections

Lecture 21: Basic Biology of Vaccination and Viral Infections (cont.) Vaccination Against Viruses: Parallels between Immunization and Infection

Lecture 22: Drug Targeting and Intracellular Drug Delivery for Vaccines Targeting Nano-carriers and Micro-carriers to Specific Cell Types Chemistry of Antibodies for Targeting Pathways of Intracellular Transport

Lecture 23: Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.) Mechanisms of Intracellular Delivery Mimicking Viral Entry Strategies

Lecture 24: DNA Vaccines Gene Therapy and DNA Immunization Mechanisms of DNA Vaccines

Lecture 25: DNA Vaccines (cont.) Delivery Systems for DNA Systemic vs. Local Delivery