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Browse materialsMIT 20.102 · Spring 2005

Macroepidemiology (BE.102)

Art: Robert Hooke, Micrographia Scheme 07, 1665 · Public domain

Instructor: Prof. William Thilly
Term: Spring 2005
Level: Undergraduate
What's inside: 1 lecture note · 1 reading · 8 other files · 4 web pages
Materials open: MIT OCW

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Source: MIT OpenCourseWare 20.102 Macroepidemiology (BE.102), Spring 2005, Prof. William Thilly — original course page on ocw.mit.edu ↗. License: CC BY-NC-SA 4.0. Study order: MIT's own listing order, section by section. Taken from MIT's published course files, downloaded from ocw.mit.edu on September 23, 2026. How RedLectern is built.

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MIT OpenCourseWare, Prof. William Thilly, 20.102 Macroepidemiology (BE.102), Spring 2005.

License: CC BY-NC-SA 4.0 · Edition: Spring 2005 · Open the original course on OCW ↗

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Macroepidemiology (BE.102)

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Lecture 1: Introduction: Dimensions of information available to define the unknown causes of common diseases

Lecture 2: Public health records and estimation of age-specific risk

Lecture 3: Effects of changes in diagnosis, prevention and therapy on historical mortality rates Sources of differences in reported incidence and mortality

Lecture 4: Mathematical models derived from histopathological observations and age-specific mortality/incidence data Examples: lung and colorectal cancers

Lecture 5: Initiation

Lecture 6: Promotion and Progression

Lecture 7: Multiparametric Analysis of Colon Cancer

Lecture 8: Multiparametric Analysis of Lung Cancer

Lecture 9: Role of Gender

Lecture 10: Sub-populations at Risk

Lecture 11: National Risk and Community Risk

Lecture 12: Familial Risk Expectations

Lecture 13: Familial Risk Observations

Lecture 14: Population Genetics

Lecture 15: Population Genetics (cont.)

Lecture 16: The search for genes carrying mutations conferring risk for common diseases

Lecture 17: The search for genes carrying mutations conferring risk for common diseases (cont.)

Lecture 18: The search for genes carrying mutations conferring risk for common diseases (cont.)

Lecture 19: The search for genes carrying mutations conferring risk for common diseases (cont.)

Lecture 20: The search for genes in which mutations of initiation (and promotion, if any) occur in common human cancers

Lecture 21: The origins of somatic and inherited mutations in humans

Lecture 22: The origins of somatic and inherited mutations in humans (cont.)

Lecture 23: Hypotheses that need testing

Lecture 24: Evolution, embryogenesis and carcinogenesis (Guest lecturer: Dr. Elena V. Gostjeva) Putting it together: Gostjeva-Thilly cascade model for risk and genesis of common clonal diseases